This popular laboratory- and computer-based course provides training in the experimental and computational approaches that can be used to mechanistically dissect important aspects of chromatin biology at the gene or genome-wide levels.

Our understanding of complex genomes has benefitted tremendously from whole genome sequencing projects. However, we are only beginning to systematically understand how the interplay of DNA, proteins and its biochemical modifications (i.e., chromatin) can influence global processes which control gene expression, mRNA splicing, and DNA replication or repair in normal development and in disease.

Learning Outcomes:
After attending the course, participants can expect to be able to:

  • Perform chromatin immunoprecipitation, 3C and Capture C, and DNA methylation techniques, including experimental design and end-point analysis.
  • Understand the methods used in the preparation of material for next generation sequencing (NGS)
  • Perform end-to-end analysis of NGS data, derived from the above methods, from raw sequence through to identifying relevant loci.
  • Download and install relevant software, and manage large datasets.
  • Understand how polymer physics can be used to build models of chromatin structures

Feedback from the 2015 course:

-The organisation of this course is superb. I have a great time in learning and discussion with participants and instructors. The course is very beneficial to me and I greatly appreciate the efforts and resources you have put into the course.
-This course was immensely helpful to furthering my expertise in chromatin biology.
-Thank you for a great course!
-Thanks to everyone for this amazing course.
-Thanks again very much for organizing this fantastic course. I appreciate all the work that went into this!
I like to thank all of the staff , orginizers, and wellcome trust for giving me this amazing opportunity to attend this great course with great people and great teachers and to learn so much!

Application Deadline:

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(or call us: +44 (0)1223 496910)