Numerous fungal species are important pathogens, affecting humans both directly (e.g. Aspergillus, Candida, Cryptococcus, Histoplasma, Pneumocystis) and indirectly through crop destruction (e.g. Fusarium, Magneporthe, Ustilago). The increasing availability and decreasing cost of sequencing technologies and other omics-scale approaches have made hundreds (and soon thousands) of fungal genomes and functional genomics datasets available for analysis. These resources will play a pivotal role in addressing and mitigating the heavy disease burden of fungal pathogens.
This exciting new week-long course aims to provide experimental biologists working on fungal organisms with hands-on experience in genomic-scale data analysis; including genome browsers and comparison tools, data mining using resources such as FungiDB, Ensembl/PhytoPathDB, PomBase, SGD/CGD, MycoCosm, analysis of genome annotation, and next generation sequence analysis and visualization (including RNA sequence analysis and variant calling). An important aim is that the participants should
understand the origin of data available in public resources and how to
analyse it in conjunction with their own.
The course is taught as a collaborative effort between available fungal informatics resources. The majority of this intensive course will be based on hands-on exercises, supplemented by lectures on genomics and bioinformatics techniques and keynote presentations by distinguished guest speakers.
After attending this course, participants should be able to:
- Interrogate large-scale genomic and functional genomic databases to answer biologically-related research questions and develop testable hypotheses
- Use software and web-based services to browse genomes, visualize next generation data and display genome comparisons
- Contribute to community annotation and curation efforts
- Use ontologies in analysis, and be aware of problems and pitfalls