This popular laboratory- and computer-based course provides training in experimental and computational approaches that can be used to mechanistically dissect important aspects of chromatin biology at the gene and genome-wide levels.

Our understanding of eukaryotic genomes has benefitted tremendously from whole genome sequencing projects. However, we are only beginning to systematically understand how the interplay of DNA, proteins and its biochemical modifications (i.e., chromatin) can influence global processes which control gene expression, mRNA splicing, and DNA replication or repair in normal development and in disease.

Learning Outcomes
After attending the course, participants can expect to be able to:

  • Perform chromatin immunoprecipitation, ATAC, 3C and Capture C, and RRBS techniques, including experimental design, end-point analysis and validation (qPCR; FISH)
  • Understand the methods used in the preparation of material for next generation sequencing (NGS)
  • Perform end-to-end analysis of NGS data, derived from the above methods, from raw sequence through to identifying relevant loci.
  • Visualise large-scale datasets in formats suitable for figures for publication
  • Download and install relevant software and manage large datasets.
  • Understand how polymer physics can be used to build models of chromatin structures

Feedback from the 2016 course
"I had never used bioinformatic tools before, and the "step-by-step" introduction we received in the course was, in my opinion, one of the most useful things I learned. Also, I take home nice advice and experience from the ATAC, FISH, RRBS and Capture-C and ChIP."
"Everything was very organized and useful. Great group of Instructors!"
"Thank you all again for this great opportunity."
"Thanks you very much for organising such an amazing course!"
"Thanks so much for organizing this course so meticulously! I appreciated every single module and came out of these nine days with a whole new understanding of how I can approach my thesis project. Very grateful for the opportunity to attend, and hope to see you all at some point in the not-so-distant future!"
"Thank you to all the instructors. I'm am really really grateful for all the hard work that they put into planning and executing the course. I feel like I gained a years worth of knowledge in just 9 days. I already feel like a more informed scientist."
"The course was immensly useful to all the students and all the instructors were perfect mentors to us."
"All instructors did an exceptionally good job - all material was very well explained and instructors were approachable and friendly - thanks!"
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(or call us: +44 (0)1223 496910)