This course provides essential training in designing, undertaking analysis and reporting experiments using mice. Participants will learn how to ensure animals of the appropriate quality are generated through the use of best practices in breeding and control of the animal environment.

Mice now account for almost 70% of animals used in scientific research, and the number of mice used continues to grow annually. Over the past few years there has been an increased focus on the enhancing validity and reproducibility of research outcomes. Preclinical research using animal models appears to be particularly susceptible to this problem. The reasons are many, and include the use of non-standardised strains and housing conditions, poor experimental design, inappropriate data analysis or inadequate reporting of experimental conditions in publications.

Applications are invited from research and scientific staff who coordinate experimental work on genetically altered mouse lines, including the maintenance of mouse colonies. Applicants should ideally have degree-standard knowledge of genetics, or equivalent.

Learning outcomes
After attending this course, participants will be able to:

  • Describe common terms associated with mouse genetics.
  • Recognise and be able to compare the most important differences between many of the common wild type strains, critically assess their influence on mouse phenotypes and use this information when selecting and manipulating genetic backgrounds for your studies.
  • Plan breeding programmes that reduce genetic drift, retaining inbred or outbred nature of genetic lines and produce cohorts of experimental animals suitable for analysis.
  • Plan and perform complex genetic crosses involving a variety of different alleles including deletions, floxed alleles and cre transgenes.
  • Construct appropriate control strategies needed when using conditional transgenesis.
  • Summarize and explain the methods by which CRISPR-Cas is used to generate mutant alleles and utilise web-based software to design and interpret newly generated mutant alleles.
  • Anticipate and troubleshoot breeding and genotype issues that might arise when performing experiments using genetically altered mice.

Bursary and Application Deadline:

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