This popular laboratory- and computer-based course provides training in experimental and computational approaches that can be used to mechanistically dissect important aspects of chromatin biology at the gene and genome-wide levels.

Our understanding of eukaryotic genomes has benefitted tremendously from whole genome sequencing projects. However, we are only beginning to systematically understand how the interplay of DNA, proteins and its biochemical modifications (i.e., chromatin) can influence global processes which control gene expression, mRNA splicing, and DNA replication or repair in normal development and in disease.

The course is aimed at PhD students, post-doctoral scientists or clinicians/healthcare professionals engaged in relevant research.

What will you learn?
After attending the course, participants can expect to be able to:

  • Perform chromatin immunoprecipitation, ATAC, 3C and Capture C, and MethylCapture techniques, including experimental design, end-point analysis and validation (qPCR; FISH)
  • Understand the methods used in the preparation of material for next generation sequencing (NGS)
  • Perform end-to-end analysis of NGS data, derived from the above methods, from raw sequence through to identifying relevant loci.
  • Download and install relevant software and manage large datasets.
  • Understand how polymer physics can be used to build models of chromatin structures

Feedback from the 2017 Course

"In 10 days, i feel as though i have gained 3 years worth of technical knowledge. I also feel 3 years older... Please continue to run this course."
"In regards to content, I felt the course was exactly as advertised and even exceeded my expectations. Much of this has to do with high level of expertise possessed by the instructors and assistants involved in teaching the labs and bioinformatics practicals."
"It was the most instructive course I had so far in molecular biology. Details about experiments are rarely discussed such in details, it was very useful for me and it will benefit all my lab."
"I would like to applaud the excellent organization and great group of Instructors of this training course, for all your efforts! I will certainly recommend the course to everyone working in the epigenetic field. The training Course was very useful and effective for me. I learned a lot and met new good people...! Thanks again."
"Thanks a lot! Amazing course and great instructors."

Application Deadline:
27 July 2018


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(or call us: +44 (0)1223 496910)