This course type is laboratory

Chromatin Structure and Function

31 October - 09 November 2016Wellcome Genome Campus, Hinxton, UK
Deadlines (at 23:59 UTC):
  • Application Deadline Closed

  • Summary

    This popular laboratory- and computer-based course provides training in
    the experimental and computational approaches that can be used to
    mechanistically dissect important aspects of chromatin biology at the
    gene or genome-wide levels.

    Our understanding of complex genomes has benefitted tremendously from
    whole genome sequencing projects. However, we are only beginning to
    systematically understand how the interplay of DNA, proteins and its
    biochemical modifications (i.e., chromatin) can influence global
    processes which control gene expression, mRNA splicing, and DNA
    replication or repair in normal development and in disease.

    Learning Outcomes:
    After attending the course, participants can expect to be able to:

    • Perform chromatin immunoprecipitation, 3C and Capture C, and DNA methylation techniques, including experimental design and end-point analysis.
    • Understand the methods used in the preparation of material for next generation sequencing (NGS)
    • Perform end-to-end analysis of NGS data, derived from the above methods, from raw sequence through to identifying relevant loci.
    • Download and install relevant software, and manage large datasets.
    • Understand how polymer physics can be used to build models of chromatin structures

    Feedback from the 2015 course:

    -The organisation of this course is superb. I have a great time in
    learning and discussion with participants and instructors. The course is
    very beneficial to me and I greatly appreciate the efforts and resources
    you have put into the course.
    -This course was immensely helpful to furthering my expertise in
    chromatin biology.
    -Thank you for a great course!
    -Thanks to everyone for this amazing course.
    -Thanks again very much for organizing this fantastic course. I
    appreciate all the work that went into this!
    I like to thank all of the staff , orginizers, and wellcome trust for
    giving me this amazing opportunity to attend this great course with great
    people and great teachers and to learn so much!

  • Programme

    Participants will receive intensive laboratory and computational training
    in state-of-the-art approaches focussed across five broad themes:

    • DNA/transcription factor interactions
    • DNA methylation
    • Histone dynamics and modifications
    • Chromatin accessibility, looping and nuclear organisation
    • Computational analysis/integration of chromatin datasets

    These sessions will be supplemented with informal tutorials and lectures
    from the instructors and distinguished invited speakers. Participants
    will analyse the various genome-wide data generated in parallel to or
    during the laboratory sessions. They will also have an opportunity to
    discuss their own research interests and present aspects of their work
    that are relevant to the course.

    Learning Outcomes:
    After attending the course, participants can expect to be able to:

    • Perform
      chromatin immunoprecipitation, 3C and Capture C, and DNA methylation
      techniques, including experimental design and end-point analysis.
    • Understand the methods used in the preparation of material for next generation sequencing (NGS)
    • Perform end-to-end analysis of NGS data, derived from the above methods, from raw sequence through to identifying relevant loci.
    • Download and install relevant software, and manage large datasets.
    • Understand how polymer physics can be used to build models of chromatin structures
  • Instructors / Speakers

    Course instructors
    David
    Vetrie
    University of Glasgow, UK
    Nick Gilbert
    University of Edinburgh, UK
    Lee Stirling, Imperial College London, UK
    Robert Andrews, Cardiff University, UK

    Guest speakers
    Adele
    Murrell
    University of Bath, UK
    Wolf
    Reik
    Babraham Institute, UK
    Dirk
    Schübeler
    Friedrich-Miescher-Institute for Biomedical Research,
    Switzerland
    Henk
    Stunnenberg
    Radboud University, The Netherlands

  • How to Apply

    Prerequisites
    Applicants should be PhD students, post-doctoral scientists or clinicians
    engaged in relevant research.

    Cost
    The
    course is subsidised by the Wellcome Genome Campus Advanced Courses
    and Scientific Conferences Programme. This is a residential
    course and
    there is a fee of £1065 towards board and lodging for non-commercial
    applicants. Please contact us for the commercial fee.

    Additional limited bursaries are available (up to 50% of the course fee)
    and are awarded on merit. Please see the “Bursaries” tab for details.

    Applications
    Applications for this course can be completed online. If you have any
    problems with the online application process, please contact us.

    Please note: Applications
    must be supported by a
    recommendation from a scientific or clinical sponsor (e.g. supervisor or
    head of department). A request for a supporting
    statement will be sent
    to your nominated sponsor automatically during
    the application process.
    Applicants must ensure that their sponsor
    provides this supporting
    statement by the application deadline. Applications without a supporting
    statement cannot be considered.

    Deadlines
    Closed

  • Bursaries

    Bursaries
    Advanced Courses are subsidised for non-commercial applicants from
    anywhere in the world. Additional, limited bursaries are
    available (up
    to 50% of the course fee) and are awarded on merit. If you would like to
    apply for a
    bursary, please complete the bursary section of the online
    application
    form.

    Please note that both the applicant
    and sponsor are required to provide
    a justification for the
    bursary as part of the application.

    Bursary terms and conditions

    UK Courses (held at the Wellcome Genome Campus, Hinxton,
    Cambridge)
    A
    limited number of bursaries are available for each course. These are
    awarded by the selection committee according to merit. The bursary
    covers a maximum of 50% of the course fee, though in exceptional
    circumstances an application for the total course fee may be considered.
    Where there are many bursary applications, the selection committee may
    issue smaller amounts. We cannot assist with travel costs to attend UK
    courses.

    Overseas Courses (held outside of the UK)
    A
    limited number of bursaries are available for each course. These are
    awarded on merit to cover travel, accommodation and sustenance. The
    maximum award for travel (economy class) will be £750.

    Bursaries can be applied for as part of the course application form.
    Applicants
    will be notified of a bursary award along with their place on
    the
    course, usually within one month of the application deadline. The
    decision of the selection committee is
    final.