New

CRISPR and beyond: perturbations at scale to understand genomes

02 - 04 September 2019Wellcome Genome Campus, UK
Deadlines (at 23:59 UTC):
  • Early bird deadline Closed
  • Bursary deadline Closed
  • Abstract deadline Closed
  • Registration deadline 30 July 2019
Register

Exploring methods to modulate the genome at scale

  • Summary

    Large scale genome sequencing has led to deep catalogues of natural and disease-related human genetic variation. Unfortunately, we do not understand the functional implications of the vast majority of detected variants, and therefore cannot use them for healthcare or research. The rapid advances of CRISPR/Cas-based technologies and DNA synthesis now make it possible to modulate genomes with relative ease. These tools can help us understand how genetic variation impacts phenotype and answer important long-standing questions in biology that also impact human health, laying the foundations for precision medicine for heritable diseases and cancer treatment.

    The programme will cover approaches that modulate the genome and its context at scale, from single nucleotides and genes to hundreds of growth environments. We will discuss (i) assays that focus on individual nucleotides in coding and non-coding regions to understand the effects of single mutations; (ii) focused- and genome-wide scrambling methods that assess the influence of changing genome structure and content; (iii) genome-wide knock-out, knock-down, and upregulation experiments to measure the phenotype when a gene is perturbed; (iv) interaction screens to uncover context-specificity of effects; and (v) small molecule treatments to understand their impact. Computational approaches are integral to all these topics, and will be covered by invited speakers, as well as sought for in submitted abstracts.

    The conference will bring together biomedical researchers working on high throughput screening, genome engineering, and/or variant effect interpretation. We welcome abstracts on all major themes of this meeting to oral or poster presentations.

  • Programme

    The conference will start at approx. 13.00 on 2 September and finish at approx. 2pm on 4 September 2019.

    Topics will include:

    • Understanding impact of coding variants
    • Measuring consequences of non-coding variation
    • Screens for gene function in cells
    • Assaying gene function in organisms
    • Gene and drug function in disease
    • Interactions with genes, drugs, and environment
    • New technology for readouts and perturbations
  • Organisers/ Speakers

    Scientific programme committee

    John Doench

    John Doench
    Broad Institute of MIT and Harvard, USA

    Jolanda van Leeuwen

    Jolanda van Leeuwen
    University of Lausanne, Lausanne, Switzerland

    Leopold Parts

    Leopold Parts
    Wellcome Sanger Institute, UK

    Lea Starita

    Lea Starita
    University of Washington, USA

    Confirmed speakers

    Britt Adamson – University of Princeton, USA
    Brenda Andrews – University of Toronto, Canada
    Michael Boutros – DKFZ Heidelberg, Germany
    Ellen Bushell – Umea University, Sweden
    Ulrich Elling –  Institute of Molecular Biology, Austria
    Douglas Fowler – Unversity of Washington, USA
    Molly Gasperini – University of Washington, USA
    Maya Ghoussaini – OpenTargets, UK
    Luke Gilbert – UCSF, USA
    Emma Haapaniemi – University of Oslo, Norway
    Ben Lehner – Centre for Genomic Regulation, Spain
    James McFarland – Broad Institute, USA
    Fritz Roth – University of Toronto, Canada
    Jussi Taipale – University of Cambridge, UK
    Sibylle Vonesch – EMBL, Germany
    Yanli Wang – Institute of Biophysics CAS, China

    Scientific Conferences Team

    Treasa Creavin, Scientific Programme Manager
    Lucy Criddle, Conference & Events Organiser

     

  • Registration/ Accommodation
    Early bird discount
    (until 11 June)

    Standard rate
    (after 11 June)
    Student No accommodation   £253 £353
    Student On-site twin accommodation   £358 £458
    Student On-site single accommodation   £423 £523
    Academic No accommodation   £353 £453
    Academic On-site twin accommodation   £458 £558
    Academic On-site single accommodation   £523 £623
    Commercial No accommodation   £453 £553
    Commercial On-site twin accommodation   £558 £658
    Commercial On-site single accommodation   £623 £723

    The registration fee includes entrance to the lectures and poster sessions, an abstract book, meals (lunch and dinner) and refreshments during the conference. Breakfast will be provided for delegates who have booked accommodation.

    Accommodation
    Accommodation is provided for the nights of 2 and 3 September 2019. Please note: there is limited onsite accommodation and this will be allocated on a first-come, first-served basis. Therefore, early registration is recommended.

    If you wish to book onsite accommodation either side of the conference dates, please contact the Conference Centre directly.

    Travel visas
    Contact the conference organiser if you require a letter to support a travel visa application. Please note: letters will only be provided to confirmed registrants.

    Non-European Economic Area or Swiss nationals may be required to have a visa to enter the UK.
    Early application is strongly advised, as this process can take 6-8 weeks or longer.

    Please visit the following websites for further information:


    Accommodation services phishing scam – please be vigilant. More information.

  • Abstracts

    We welcome abstracts from all areas relevant to the main themes of the meeting, for both oral and poster presentations. Several oral presentations will be chosen from the abstracts submitted.

    Abstracts will only be considered from registered delegates. Please use our online abstract submission system and follow the instructions given to ensure your abstract is submitted correctly. All abstracts must be submitted by the deadline. If you are intending to submit more than one abstract, please contact the conference organiser prior to registration.

    The scientific programme committee will assess your abstract after the deadline has passed and you will be notified whether you have been selected for an oral or poster presentation.

    Poster boards onsite will accommodate 118 cm high by 84 cm wide (A0- portrait) of printed material. Accepted abstracts will appear in the conference programme book and poster boards will be allocated at the conference.

    Abstract deadline: 9 July 2019

  • Bursaries

    A limited number of registration bursaries are available for PhD students to attend this conference (up to 50% of the standard registration fee) from Wellcome Genome Campus Scientific Conferences.

    To apply, please contact the conference organiser. You will be sent a unique registration link which will hold your place, without taking payment, until you have been notified of the outcome of your application.

    The following documents will need to be provided as part of the bursary application:

    • Abstract (to be submitted via the portal during the registration process)
    • CV
    • A justification letter (explain how you will benefit from attending the conference)
    • A supporting letter from supervisor stating financial need

    If you have already registered for the conference you are still welcome to apply for a bursary, please contact the conference organiser.

    Bursary deadline: 25 June 2019

    Additional funding opportunities
    Visit our support page for additional financial support currently available.

  • Sponsors

    Our CRISPR conference has been made possible thanks to our valued sponsors.

    With special thanks to our Gold Sponsor:

    10x Genomics
    10x Genomics – Gold Sponsor

     

    Thanks to our Bronze sponsor: 

    AMS Biotechnology – Bronze Sponsor

     

     

    If you are interested in supporting this meeting, please contact the conference organiser.