CRISPR and Beyond: Perturbations at Scale to Understand Genomes

23 - 25 September 2020Wellcome Genome Campus, UK
Deadlines (at 23:59 UTC):
  • Early bird deadline 23 June 2020
  • Bursary deadline 07 July 2020
  • Abstract deadline 21 July 2020
  • Registration deadline 01 September 2020

Exploring methods to modulate the genome at scale

  • Summary

    We are pleased to announce our second conference on genetic perturbations at scale. The development of CRISPR/Cas-based technologies and DNA synthesis make it possible to modulate genomes with relative ease. These tools can help us understand how genetic variation influences phenotype and thereby answer long-standing questions in biology that impact human health, laying the foundations for precision medicine for heritable diseases and cancer treatment.

    This rapid advancement in gene-editing technology enables us to begin to understand the functional implications of natural and disease-related human genetic variation. This year’s programme will cover approaches that modulate the genome and its context at scale, from single nucleotides and genes to hundreds of growth environments.

    We will discuss (i) assays that focus on individual nucleotides in coding and non-coding regions to understand the effects of single mutations; (ii)  focused- and genome-wide randomization methods that assess the influence of changing sequence structure and content; (iii) genome-wide knock-out, knock-down, and upregulation experiments to measure the phenotype when a gene is perturbed; (iv) interaction screens to uncover context-specificity of effects; (v) methods and applications of gene editing (vi) single cell readouts and other emerging technologies. Computational approaches are integral to all these topics, and will be covered by invited speakers, as well as sought for in submitted abstracts.

    The conference will bring together biomedical researchers working on high throughput screening, genome engineering, and/or variant effect interpretation. We welcome abstracts on all major themes of this meeting to oral or poster presentations.

  • Programme

    The conference will start at approx. 13.00 on 23 September and finish at approx. 14.00 on 25 September 2020.

    Topics will include:

    • Understanding impact of coding variants
    • Measuring consequences of non-coding variation
    • Genetic screens to ascertain function in cells and organisms
    • Base editing at scale
    • Gene editing and disease
    • Interactions with genes, drugs, and environment
    • Single-cell approaches
    • New technology for readouts and perturbations
  • Organisers/ Speakers

    Scientific programme committee

    John Doench

    John Doench
    Broad Institute of MIT and Harvard, USA

    Jolanda van Leeuwen

    Jolanda van Leeuwen
    University of Lausanne, Lausanne, Switzerland

    Leopold Parts

    Leopold Parts
    Wellcome Sanger Institute, UK

    Lea Starita

    Lea Starita
    University of Washington, USA

    Confirmed speakers

    Kenneth Baille – University of Edinburgh, UK
    Kristen Brennand – Ichan School of Medicine at Mount Sinai, USA
    Barak Cohen – Washington University School of Medicine, USA
    Maitreya Dunham – University of Washington, USA
    Tom Ellis – Imperial College London, UK
    Matthew Garnett – Wellcome Sanger Institute, UK
    Jay Hesselberth – University of Colorado School of Medicine, USA
    Rory Johnson – University College Dublin, Ireland
    Joanna Loizou – CeMM Research Center for Molecular Medicine, Austria
    Nozomu Myachie – University of Tokyo, Japan
    Sylvie Noordermeer – Leiden University Medical Centre, The Netherlands
    Shondra Pruett-Miller – St Judes Children’s Research Hospital, USA
    Lea Starita – University of Washington, USA
    Wensheng Wei – Peking University, China

    Conference organisers

    Lucy Criddle, Conference & Events Organiser
    Treasa Creavin, Scientific Programme Manager

  • Registration / Accommodation
    Early bird discount
    (until 23 June)

    Standard rate
    (after 23 June)
    Student No accommodation £277.00 £377.00
    Student On-site twin accommodation £384.00 £484.00
    Student On-site single accommodation £450.00 £550.00
    Academic No accommodation £377.00 £477.00
    Academic On-site twin accommodation £484.00 £584.00
    Academic On-site single accommodation £550.00 £650.00
    Commercial No accommodation £477.00 £577.00
    Commercial On-site twin accommodation £584.00 £684.00
    Commercial On-site single accommodation £650.00 £750.00

    The registration fee includes entrance to the lectures and poster sessions, an abstract book, meals (lunch and dinner) and refreshments during the conference. Breakfast will be provided for delegates who have booked accommodation.

    Accommodation is provided for the nights of 23 and 24 September 2020. Please note: there is limited onsite accommodation and this will be allocated on a first-come, first-served basis. Therefore, early registration is recommended.

    If you wish to book onsite accommodation either side of the conference dates, please contact the Conference Centre directly.

    Travel visas
    Contact the conference organiser if you require a letter to support a travel visa application. Please note: letters will only be provided to confirmed registrants.

    Non-European Economic Area or Swiss nationals may be required to have a visa to enter the UK.
    Early application is strongly advised, as this process can take 6-8 weeks or longer.

    Please visit the following websites for further information:

    Accommodation services phishing scam – please be vigilant. More information.


  • Abstracts

    We welcome abstracts from all areas relevant to the main themes of the meeting, for both oral and poster presentations. Several oral presentations will be chosen from the abstracts submitted.

    Abstracts will only be considered from registered delegates. Please use our online abstract submission system and follow the instructions given to ensure your abstract is submitted correctly. All abstracts must be submitted by the deadline. If you are intending to submit more than one abstract, please contact the conference organiser prior to registration.

    The scientific programme committee will assess your abstract after the deadline has passed and you will be notified whether you have been selected for an oral or poster presentation.

    Poster boards onsite will accommodate 118 cm high by 84 cm wide (A0- portrait) of printed material. Accepted abstracts will appear in the conference programme book and poster boards will be allocated at the conference.

    Abstract deadline: 21 July 2020

    How to upload an abstract once you have already completed registration:

    1. Log back into your registration account using either Firefox or Internet Explorer as your browser, via link above the ‘Share’ button on the right hand column of this page
    2. Click on ‘Account’ (top right).
    3. Then click on ‘View account history’. This will show a table of your event registrations.
    4. In the right-hand column you will see the option to ‘Upload file’ – click on this and select to upload an abstract.
  • Bursaries

    A limited number of registration bursaries are available for PhD students to attend this conference (up to 50% of the standard registration fee) from Wellcome Genome Campus Scientific Conferences.

    To apply, please contact the conference organiser. You will be sent a unique registration link which will hold your place, without taking payment, until you have been notified of the outcome of your application.

    The following documents will need to be provided as part of the bursary application:

    • Abstract (to be submitted via the portal during the registration process)
    • CV
    • A justification letter (explain how you will benefit from attending the conference)
    • A supporting letter from supervisor stating financial need

    If you have already registered for the conference you are still welcome to apply for a bursary, please contact the conference organiser.

    Bursary deadline: 7 July 2020

    Additional funding opportunities
    Visit our support page for additional financial support currently available.

  • Sponsors

    Our CRISPR and Beyond conference has been made possible thanks to our valued sponsors.

    A special thank you to our Gold Sponsor: 

    10X Genomics – Gold Sponsor



    If you are interested in supporting this meeting, please contact the conference organiser.