This course type is lecture

Mouse Models: Genetics, Breeding and Experimental Design

13 - 17 June 2016Wellcome Genome Campus, Hinxton, UK
Deadlines (at 23:59 UTC):
  • Application Deadline Closed

  • Summary

    This popular course provides essential training in designing, undertaking
    analysis and reporting experiments using mice. In addition, participants
    will learn how to ensure animals of the appropriate quality are generated
    through the use of best practices in breeding and control of the animal
    environment.

    The course (formally Genetics, Breeding and Welfare of Laboratory Mice)
    is a collaboration between the MRC Harwell, South Australian Health and
    Medical Research Institute and the Wellcome Trust Sanger Institute. The
    content has continually evolved to meet the requirements of the mouse
    research community. The focus this year will be on experimental design to
    maximise animal welfare and the application of the 3Rs.

    Mice now account for almost 70% of animals used in scientific research,
    and the number of mice used continues to grow annually. Over the past few
    years there has been an increased focus on the enhancing validity and
    reproducibility of research outcomes. Preclinical research using animal
    models appears to be particularly susceptible to this problem. The
    reasons are many, and include the use of non-standardised strains and
    housing conditions, poor experimental design, inappropriate data analysis
    or inadequate reporting of experimental conditions in publications.

    Applications are invited from research and scientific staff who
    coordinate experimental work on genetically altered mouse lines,
    including the maintenance of mouse colonies. Applicants should ideally
    have degree-standard knowledge of genetics, or equivalent.

  • Programme

    The course will start at approximately 9.00 on Monday, 13 June and close
    at approximately 16.30 on Friday, 17 June 2016. This is a residential
    course. All students are requested
    to stay onsite for the full duration
    to benefit fully from discussions
    and interactions with the faculty and
    other students.

    Topics will include:

    • Overview of mouse genetics & strains
    • Gene & strain nomenclature
    • Aspects of good colony management
    • Breeding strategies for maintaining inbred, outbred and genetically altered lines
    • Establishing and maintaining transgenic lines and gene targeted lines
    • Conditional and inducible transgenesis
    • CRISPR/Cas9 and emerging technologies for generating GA colonies
    • Genotyping
    • Quality control strategies for mouse lines
    • Workshops on designing breeding programs
    • Cryopreservation
    • Electronic tools for colony management
    • Experimental design:
      • Randomisation and blinding
      • The experimental unit
      • Calculating experimental numbers
      • The 3Is
      • Ethics and the 3Rs
      • Experimental controls
      • Statistical analysis
      • Standardisation and variability: effects of the environment, time and health status on experimental results
    • Pilot experiments
  • Instructors / Speakers

    Scientific programme committee 
    James Bussell Wellcome Trust
    Sanger Institute, UK
    Neil Dear South Australian Health and Medical
    Research Institute, Australia
    Sara Wells MRC Harwell, UK

    Keynote speakers
    Ian Jackson 
    University of Edinburgh, UK
    Patrick Bateson University of Cambridge, UK

    Confirmed tutors
    Ben Davies
    University of Oxford, UK
    Martin Fray MRC Harwell, UK
    Andy Greenfield MRC Harwell, UK
    Elliot Lilley RSPCA, UK
    Terry Meehan EMBL-EBI, UK
    Ed Ryder Wellcome Trust Sanger Institute, UK
    Lydia Teboul MRC Harwell, UK

    Event organiser
    Emily Rees Wellcome Genome Campus, UK

  • How to Apply

    Fees

    Registration with Single Accommodation  £375

    The fees include accommodation, meals and lectures for the duration of
    the course. The fee will be requested once acceptance is confirmed.

    Accommodation
    This is a residential course. All participants will stay at The Wellcome
    Genome Campus Conference Centre, Hinxton, Cambridge, for the nights of
    13, 14, 15 & 16 June 2016.

    If you wish to book onsite accommodation either side of the summer
    school/course dates, please contact the Conference
    Centre
    directly.

    Applications
    Application deadline: 22 April 2016 (Now closed for
    applications)

    Places on this course are limited to 30 students and will be awarded on
    merit. Applications are invited from research and scientific staff who
    coordinate experimental work on genetically altered mouse lines,
    including the maintenance of mouse colonies. Applicants should ideally
    have degree-standard knowledge of genetics, or equivalent. The selection
    process will take place in late April 2016.

    The following will need to be provided:

    • Qualifications and justification for attendance
    • A list of relevant publications
    • A scientific outline of current research
    • Supervisor’s details: your supervisor will then receive an e-mail requesting a supporting statement to complete your application.

    Please note: Applications cannot be considered without a
    supervisor’s supporting statement.

    Travel visas
    Please contact the event organiser if you require a letter to support a
    travel visa application. Note that letters will be provided to confirmed
    attendees.

    Non-European Economic Area or Swiss nationals may be required to have a
    visa to enter the UK.
    Early application is strongly advised, as this process can take 6-8 weeks
    or longer.

    Please visit the following websites for further information:
    UK Border Agency website: www.ukba.homeoffice.gov.uk/visas-immigration/

    Information for general visitors and business visitors: www.ukba.homeoffice.gov.uk/visas-immigration/visiting/business/business-activities/

  • Sponsors

    Please note there are no bursaries or travel grants available for this
    course/summer school.

    or

    A limited number of registration bursaries are
    available for PhD
    students to attend this course/summer school (up to 50% of the
    fee).

    The following documents will need to be provided:

    • CV
    • Covering letter
    • Letter from supervisor

    To apply, please contact the event organiser.

    Bursary deadline: 5 July 2015