This course type is lecture

Mouse Models: Genetics, Breeding and Experimental Design

23 - 27 July 2018Wellcome Genome Campus, Hinxton, UK
Deadlines (at 23:59 UTC):
  • Bursary and Application Deadline Closed

  • Summary

    This course provides essential training in designing, undertaking
    analysis and reporting experiments using mice. Participants will learn
    how to ensure animals of the appropriate quality are generated through
    the use of best practices in breeding and control of the animal
    environment.

    Mice now account for almost 70% of animals used in scientific research,
    and the number of mice used continues to grow annually. Over the past few
    years there has been an increased focus on the enhancing validity and
    reproducibility of research outcomes. Preclinical research using animal
    models appears to be particularly susceptible to this problem. The
    reasons are many, and include the use of non-standardised strains and
    housing conditions, poor experimental design, inappropriate data analysis
    or inadequate reporting of experimental conditions in publications.

    Applications are invited from research and scientific staff who
    coordinate experimental work on genetically altered mouse lines,
    including the maintenance of mouse colonies. Applicants should ideally
    have degree-standard knowledge of genetics, or equivalent.

    Learning outcomes
    After attending this course, participants will be able to:

    • Describe common terms associated with mouse genetics.
    • Recognise and be able to compare the most important differences between many of the common wild type strains, critically assess their influence on mouse phenotypes and use this information when selecting and manipulating genetic backgrounds for your studies.
    • Plan breeding programmes that reduce genetic drift, retaining inbred or outbred nature of genetic lines and produce cohorts of experimental animals suitable for analysis.
    • Plan and perform complex genetic crosses involving a variety of different alleles including deletions, floxed alleles and cre transgenes.
    • Construct appropriate control strategies needed when using conditional transgenesis.
    • Summarize and explain the methods by which CRISPR-Cas is used to generate mutant alleles and utilise web-based software to design and interpret newly generated mutant alleles.
    • Anticipate and troubleshoot breeding and genotype issues that might arise when performing experiments using genetically altered mice.
  • Programme

    The course will start at approximately 12:00
    on Monday, 23 July and close
    at approximately 14:00 on Friday, 27 July 2018.

    Topics will include:

      •    Overview of mouse genetics & strains
      •    Gene & strain nomenclature
      •    Aspects of good colony management
      •    Breeding strategies for maintaining inbred, outbred and genetically altered lines
      •    Conditional and inducible transgenesis
      •    CRISPR/Cas9 and emerging technologies for generating GA colonies
      •    Genotyping

    This
    is a residential course. All students are requested to stay onsite
    for
    the full duration to benefit fully from discussions and interactions
    with the faculty and other students.

    A draft
    programme
    is available.

  • Instructors / Speakers

    Scientific programme committee
    James Bussell Wellcome Sanger Institute,
    UK
    Neil Dear
    University of Leicester, UK
    Sara Wells
    MRC Harwell, UK

    Keynote speakers
    Ian Jackson University of Edinburgh, UK
    George Vassiliou
    Wellcome Sanger Institute, UK

    Confirmed tutors
    James Bussell Wellcome Sanger Institute, UK
    Ben Davies University of Oxford, UK
    Neil Dear University of Leicester, UK
    Ed Ryder Wellcome Sanger Institute, UK
    Michelle Stewart MRC, UK
    Aurelie Thomas Wellcome Sanger Institute, UK
    Sara Wells MRC Harwell,
    UK

    Event organiser
    Sue Taylor Wellcome Genome Campus, UK

  • How to Apply

    Fees

    Registration with Single Accommodation  £670

    The fees include accommodation, meals and lectures for the duration of
    the course. The fee will be requested once acceptance is confirmed.

    Accommodation
    This is a residential course. All participants will stay at The Wellcome
    Genome Campus Conference Centre, Hinxton, Cambridge, for the nights of
    23, 24, 25 and 26 July 2018. 

    If you wish to book onsite accommodation either side of the course dates,
    please contact the Conference
    Centre
    directly.

    Applications
    Application deadline: 1 May 2018

    Places on this course are limited and will be awarded on merit.
    Applicants should be PhD students currently engaged in relevant research
    and have a working knowledge of genetics. All applicants will be required
    to complete an online application form.
    The selection process will take place in May 2018.

    The following will need to be provided:

    • Qualifications and justification for attendance
    • Supervisor’s details: your supervisor will then receive an e-mail requesting a supporting statement to complete your application.

    Please note: Applications cannot be considered without a
    supervisor’s supporting statement.

    Travel visas
    Please contact the event organiser if you require a letter to support a
    travel visa application. Note that letters will be provided to confirmed
    attendees.

    Non-European Economic Area or Swiss nationals may be required to have a
    visa to enter the UK.
    Early application is strongly advised, as this process can take 6-8 weeks
    or longer.

    Please visit the following websites for further information:
    UK Border Agency website: www.ukba.homeoffice.gov.uk/visas-immigration/

    Information for general visitors and business visitors:
    www.ukba.homeoffice.gov.uk/visas-immigration/visiting/business/business-activities/

  • Bursaries

    A limited number of registration bursaries are
    available to attend this course (up to 50% of the
    fee).

    The following documents will need to be provided:

    • CV
    • A justification letter from applicant
    • A supporting letter from supervisor stating financial need

    To apply, please contact the event organiser.

    Bursary deadline: 1 May 2018

    Additional funding opportunities
    Visit
    our Funding webpage
    for additional funding opportunities currently
    available.

  • Sponsors

    If you are interested in supporting this course, please contact the event organiser.