This course type is lecture

Practical Aspects of Small Molecule Drug Discovery: At the Interface of Biology,

19 - 24 June 2016Wellcome Genome Campus, Hinxton, UK
Deadlines (at 23:59 UTC):
  • Application Deadline Closed

  • Summary

    A growing number of investigators in leading research institutions and
    small and medium-sized companies are expanding from their strength in
    disease biology into early-stage drug discovery. However, this move
    requires successfully combining the disciplines of biochemistry,
    medicinal chemistry, pharmacokinetics and pharmacology, the breadth of
    which can present organisational, knowledge and competence challenges for
    institutions and investigators.

    This interactive, lecture- and discussion-based course is held biennially
    and aims to give researchers of any discipline a broad introduction to
    the theoretical, practical and organisational aspects of small molecule
    drug discovery. Each topic will include a lecture together with
    discussion sessions and case histories to develop key aspects highlighted
    in the lectures. In addition there will be practical sessions to
    illustrate the beginnings of drug discovery programmes, including the
    production of target product profiles, compound progression criteria and
    scientific strategy.

    Feedback from the 2014 course:
    “The course covers everything on state-of-art drug discovery in the
    pharmaceutical industry. Completely relevant and excellent.”
    “The course provided an excellent introduction to many subject areas
    covered with further reading suggested for those
    requiring more in depth information.”
    “I think this course was very comprehensive, it covered all the areas of
    drug discovery with excellent depth.”
    “Thank you very much for the opportunity to attend such a useful
    “Thank you for a great experience during the course.”

  • Programme

    The programme will include lectures and discussions covering the
    following topics:

    • Project management and organisation of multi-disciplinary projects
    • Target discovery and validation
    • Hit discovery options
    • Fragment based drug discovery
    • Phenotypic screening and mode of action elucidation
    • Screening set selection, storage and quality control
    • Screening cascades, assay development and quality control
    • Data mining
    • Introduction to pharmacokinetics
    • Principles of compound optimisation and case histories
    • In silico approaches to drug design
    • Intellectual property strategy
    • Data packages required for out licensing and partnering
    • An introduction to preclinical and clinical development
  • Instructors / Speakers

    Course organisers
    Paul Wyatt Head of the Drug Discovery Unit, University
    of Dundee, UK
    Mary Donnelly MDPharmasolutions, ex-GSK

    Guest lecturers
    Each year, a prestigious panel of guest lecturers from industry, academia
    and established not-for-profit organisations is assembled for the course.
    Guest lecturers in previous years have included senior representatives

    Astex Pharmaceuticals
    BioFocus DPI Ltd
    European Bioinformatics Institute
    Medical Research Council Technology
    University of Dundee
    Albany Regulatory Consulting Limited
    Imperial College

  • How to Apply

    Applicants will likely be:

    • new postdoctoral recruits to already established facilities
    • postdoctoral grade researchers in small or medium sized companies
    • senior investigators considering entering the field
    • recipients, and their staff, of Seeding Drug Discovery project funding
    • established investigators seeking further professional development

    course is subsidised by the Wellcome Genome Campus Advanced Courses
    and Scientific Conferences Programme. This is a residential
    course and
    there is a fee of £615 towards board and lodging.

    Applications for this course can be completed online. If you have any
    problems with the online application process, please contact us.

    Please note: Applications
    must be supported by a
    recommendation from a scientific or clinical sponsor (e.g. supervisor or
    head of department). A request for a supporting
    statement will be sent
    to your nominated sponsor automatically during
    the application process.
    Applicants must ensure that their sponsor
    provides this supporting
    statement by the application deadline. Applications without a supporting
    statement cannot be considered.

    Deadline for Applications: Closed

  • Bursaries

    Advanced Courses are subsidised for non-commercial applicants from
    anywhere in the world. Additional, limited bursaries are
    available (up
    to 50% of the course fee) and are awarded on merit. If you would like to
    apply for a
    bursary, please complete the bursary section of the online

    Please note that both the applicant
    and sponsor are required to provide
    a justification for the
    bursary as part of the application

    Bursary terms and conditions

    UK Courses (held at the Wellcome Genome Campus, Hinxton,
    limited number of bursaries are available for each course. These are
    awarded by the selection committee according to merit. The bursary
    covers a maximum of 50% of the course fee, though in exceptional
    circumstances an application for the total course fee may be considered.
    Where there are many bursary applications, the selection committee may
    issue smaller amounts. We cannot assist with travel costs to attend UK

    Overseas Courses (held outside of the UK)
    limited number of bursaries are available for each course. These are
    awarded on merit to cover travel, accommodation and sustenance. The
    maximum award for travel (economy class) will be £750.

    Bursaries can be applied for as part of the course application form.
    will be notified of a bursary award along with their place on
    course, usually within one month of the application deadline. The
    decision of the selection committee is